The editing mutation, Polg(D257A), in mitochondrial DNA polymerase improves
diabetes in Akita male mice by suppressing appetite.
Summary Data Summary
Investigator Smithies, Oliver
Description Not Specified
Status In Progress
Public Release 4/6/2011
Data Collected? Data will not be collected for this catalog item
Species M. musculus
Animal Age Measured In: day(s) post-natal (d)
Data Analysis

TypeCountReleased
Animals83-
Experimental Conditions1-
Phenotype Assays13-
Phenotype Measurements15681568
Microarrays0-
Histology Images1010
Publications0-


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6J
0
1
0
B6-Akita
1
7
0
B6-Akita-Polg/+
9
24
0
B6-Akita-Polg-/-
10
30
0
B6-Polg
0
1
0


Histology Images
CaptionStrainAnatomical Site
Electron micrograph of Polg Akita proximal tubular cell [Consortial]C57BL6-Ins2Akita/+-PolgD257A/+kidney
Light microscopy of renal proximal and distal tubules [Consortial]C57BL6-Ins2Akita/+-PolgD257A/+kidney cortex
Electron micrograph of Akita distal tubular cells with glycogen deposits [Consortial]C57BL6-Ins2Akita/+-PolgD257A/+kidney cortex
Light microscopy of test of B6 Akita [Consortial]C57BL6-Ins2Akita/+
H&E from Akita diabetic mouse [Consortial]C57BL6-Ins2Akita/+pancreas
Light microscopy of Polg Akita mouse [Consortial]C57BL6-Ins2Akita/+-PolgD257A-/-kidney cortex
Light microscopy of testis of B6 polg-Akita [Consortial]C57BL6-Ins2Akita/+-PolgD257A-/-
Light microscopy of kidney of Polg Akita diabetic mouse [Consortial]C57BL6-Ins2Akita/+-PolgD257A-/-pancreas
Light microscopy of testis of wild type mouse [Consortial]C57BL/6J
Light microscopy of testis of Polg Akita diabetic mouse [Consortial]C57BL6-PolgD257A/+



No documents found.