Laboratory Smithies
Experiment The editing mutation, Polg(D257A), in mitochondrial DNA polymerase improves diabetes in Akita male mice by suppressing appetite.
Caption Electron micrograph of Akita distal tubular cells with glycogen deposits [Consortial]
Strain C57BL6-Ins2-Polg
Animal ID 0613-06
Animal Age 270 day(s) post-natal (d)
Anatomical Site kidney cortex (External Reference)
External Sample ID
Tissue Collection Date Not Specified
Slide Preparation Date Not Specified
Image Acquisition Date Not Specified
Staining Protocol aldehyde fuchsin
Available? Unavailable
Block ID Not Specified
Block Type Not Specified
Sectioning Investigator Not Specified
Magnification Level 2500 X
Gross Description
Microscopic Description Electron micrograph of Akita distal tubular cells with glycogen deposits within
the nuclei.


AssayAgeMeasured ValueMissing DataComments
 ACR 270urine albumin/urine creatinine ratio 10.943  
 energy intake (24 hr) 270energy intake (24 hr) 8.695  
 Kid:BW 270total kidney:body weight ratio 0.00928  
 plasma glucose 270glucose, plasma 153.751  
 pTG 270plasma triglycerides 19.473  
 R Kid Wt 270right kidney weight (mouse) 0.257  
 total ualb 270total albumin excretion 40.358  
 ucreat 270creatinine, urine (Exocell Picric Acid method) 10.84677  
 glucose, urine 270glucose, urine 88.65  
 urine output 270urine output 34  
 W rodent 270body mass 22.933  
 water intake 270water intake 39.02