Lower serum osteocalcin concentrations in patients with type 2 diabetes and
relationships with vascular risk factors among patients with coronary artery
Authors Darwish L, Nguyen MM, Saleem M, Eakin KA, Herrmann N, Sugamori KS, Oh PI, Yang
P, Mitchell J, Lanctôt KL, Swardfager W
Submitted By Walter Swardfager on 4/8/2019
Status Published
Journal Journal of diabetes and its complications
Year 2019
Date Published
Volume : Pages 33 : 390 - 397
PubMed Reference 30799280
Abstract Lower serum concentrations of the osteoblast-derived protein, osteocalcin, have
been associated with poorer glycemic control, insulin resistance and
atherosclerosis, and with the development of type 2 diabetes (T2DM)., This study
compares concentrations of two physiological forms of osteocalcin, carboxylated
(cOCN) and uncarboxylated (unOCN), between participants with T2DM (n?=?20) and
age-, gender- and body mass index (BMI)-matched participants without T2DM
(n?=?40) among patients with coronary artery disease (CAD), and it explores
relationships between osteocalcin concentrations and cardiovascular risk
factors., Concentrations of unOCN (2.71?±?1.86 vs. 4.70?±?2.03?ng/mL;
t?=?-3.635, p?=?0.001) and cOCN (8.70?±?2.27 vs. 10.77?±?3.69?ng/mL; t?=?-2.30,
p?=?0.025) were lower in participants with T2DM. In participants without T2DM,
concentrations of cOCN were associated with fitness (VO2Peak rho?=?0.317,
p?=?0.047) and lower body fat (rho?=?-0.324, p?=?0.041). In participants with
T2DM, lower unOCN was associated with HbA1c (rho?=?-0.516, p?=?0.020). Higher
body mass was associated with higher unOCN (rho?=?0.423, p?=?0.009) in
participants without T2DM, but with lower concentrations of both unOCN
(rho?=?-0.590, p?=?0.006) and cOCN (rho?=?-0.632, p?=?0.003) in participants
with T2DM., In patients with CAD, lower osteocalcin concentrations were related
to type 2 diabetes, and to adverse fitness, metabolic and obesity profiles.

Investigators with authorship
Walter SwardfagerSunnybrook Hospital