Emerging Targets for Cardiovascular Disease Prevention in Diabetes.
Authors Stitziel NO, Kanter JE, Bornfeldt KE
Submitted By Submitted Externally on 8/11/2020
Status Published
Journal Trends in molecular medicine
Year 2020
Date Published 8/1/2020
Volume : Pages 26 : 744 - 757
PubMed Reference 32423639
Abstract Type 1 and type 2 diabetes mellitus (T1DM and T2DM) increase the risk of
atherosclerotic cardiovascular disease (CVD), resulting in acute cardiovascular
events, such as heart attack and stroke. Recent clinical trials point toward new
treatment and prevention strategies for cardiovascular complications of T2DM.
New antidiabetic agents show unexpected cardioprotective benefits. Moreover,
genetic and reverse translational strategies have revealed potential novel
targets for CVD prevention in diabetes, including inhibition of apolipoprotein
C3 (APOC3). Modeling and pharmacology-based approaches to improve insulin action
provide additional potential strategies to combat CVD. The development of new
strategies for improved diabetes and lipid control fuels hope for future
prevention of CVD associated with diabetes.