Serum osteocalcin is associated with subjective stress in people with depression
and type 2 diabetes.
Authors Nguyen MM, Anita NZ, Darwish L, Major-Orfao C, Colby-Milley J, Wong SK, Sugamori
KS, Lanctôt KL, Herrmann N, Oh PI, Yang P, Shah BR, Gilbert J, Assal A, Halperin
IJ, Mitchell J, Swardfager W
Submitted By Walter Swardfager on 11/20/2020
Status Published
Journal Psychoneuroendocrinology
Year 2020
Date Published 9/1/2020
Volume : Pages 122 : 104878
PubMed Reference 33038647
Abstract Low serum osteocalcin is a risk factor for type 2 diabetes mellitus (T2DM), and
osteocalcin release from bone is associated with an acute stress response in
mice. Both diabetes and stress are associated with depression. Here, we assess
relationships between serum osteocalcin, depression and subjective stress in
people with T2DM., Participants with T2DM (HbA1c above 6.4 %, impaired fasting
glucose or impaired glucose tolerance) were assessed for a major depressive
episode using the research version of the Structured Clinical Interview for
DSM-5 depression criteria (SCID-5RV). Subjective stress over the past month was
assessed using the Perceived Stress Scale (PSS). Serum carboxylated (cOCN) and
fully decarboxylated (dcOCN) osteocalcin were assayed from fasting morning blood
by commercial enzyme-linked immunosorbent assay., Among 95 participants (mean
age 62.4 ± 9.9, 51 % women), 22 % were experiencing a depressive episode (9 men,
12 women). The presence of a depressive episode was not associated with dcOCN or
cOCN concentrations; however, higher concentrations of cOCN were associated with
higher PSS scores in participants with depression (r = 0.585, p = 0.005). In an
analysis of covariance model controlling for age, sex, body mass index, glycemic
control (glycosylated hemoglobin), insulin resistance (homeostatic model),
depression, and antidepressant use, cOCN was associated with PSS scores
(F=10.302, p = 0.002), and this relationship was stronger in those with
depression (depression × cOCN interaction F=4.978, p = 0.028). Although
associations between dcOCN concentrations and PSS scores did not reach
significance, the same trend seen with cOCN concentrations was observed in
participants with depression for dcOCN (r=0.365, p=0.10), and for a depression ×
dcOCN interaction associated with PSS scores in the whole group (F=2.165, p =
0.15)., Osteocalcin is a neuroendocrine marker associated with perceived chronic
stress among people with T2DM experiencing a depressive episode.

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