NOD.Cg-Prkdcscid Il2rgtm1Wjl Leprdb-5J/Sz

Summary Data Summary
Species M. musculus
Official Name NOD.Cg-Prkdcscid Il2rgtm1Wjl Leprdb-5J/Sz
Common Name NOD scid gamma lepr
Description These mutant mice combine the features of the NOD/ShiLtJ
background, the severe combined immune deficiency mutation
(scid) and IL2 receptor gamma chain deficiency with the
Lepr mutation.
Development Status Phenotyping ongoing
Background NOD/Shi
Breeding Type intercross
Phenotype Description NOD.Cg-Prkdc Il2rg Lepr/Sz mice lack
mature T cells, B cells, or functional NK cells, and are
deficient in cytokine signaling. Mice homozygous for the
diabetes spontaneous mutation (Leprdb) become obese at
approximately three to four weeks of age. Elevations of
plasma insulin begin at 10 to 14 days and elevations of
blood sugar at four to eight weeks. Homozygous mutant mice
are polyphagic, polydipsic, and polyuric.
Investigators 1
Genomics - Modifications 3

Leonard ShultzJackson Laboratory

Genomic Information
GeneAllele 1Allele 2Protocol
Prkdcpoint mutation - transversionpoint mutation - transversionNot Specified
Il2rgknockoutknockoutNot Specified
Leprpoint mutation - transversionpoint mutation - transversionNot Specified