Ossabaw

Summary Data Summary
Species S. scrofa
Official Name Ossabaw
Common Name Ossabaw miniature swine
Description Ossabaw swine have a 'thrifty genotype' (propensity to
obesity) that enables them to survive seasonal food
shortages in their native environment. Consumption of excess
kcal causes animals of the thrifty genotype to manifest
components of the metabolic syndrome, including central
(intra-abdominal) obesity, insulin resistance, impaired
glucose tolerance, dyslipidemia, and hypertension. We
determined whether female Ossabaw swine manifest multiple
components of the metabolic syndrome by comparing lean pigs
fed a normal maintenance diet (7% kcal from fat; lean, n =
9) or excess chow with 45% kcal from fat and 2% cholesterol
(obese, n = 8). After 9 wk, body composition, glucose
tolerance, plasma lipids, and intravascular ultrasonography
and histopathology of coronary arteries were assessed.
Computed tomography (CT) assessed subcutaneous and
intra-abdominal fat deposition and was compared with
traditional methods, including anatomical measurements,
backfat ultrasonography, and proximate chemical composition
analysis. Compared with lean animals, obese swine showed
2-fold greater product of the plasma insulin × glucose
concentrations, 4.1-fold greater total cholesterol, 1.6-fold
greater postprandial triglycerides, 4.6-fold greater low- to
high-density lipoprotein cholesterol ratio, hypertension,
and neointimal hyperplasia of coronary arteries. The
1.5-fold greater body weight in obese swine was largely
accounted for by the 3-fold greater carcass fat mass. High
correlation (0.79 to 0.95) of CT, anatomical measurements,
and ultrasonography with direct chemical measures of
subcutaneous, retroperitoneal, and visceral fat indicates
high validity of all indirect methods.
Development Status Phenotyping complete
Breeding Type intercross
Phenotype Description Ossabaw swine have a 'thrifty genotype' (propensity to
obesity) that enables them to survive seasonal food
shortages in their native environment. Consumption of excess
kcal causes animals of the thrifty genotype to manifest
components of the metabolic syndrome, including central
(intra-abdominal) obesity, insulin resistance, impaired
glucose tolerance, dyslipidemia, and hypertension. We
determined whether female Ossabaw swine manifest multiple
components of the metabolic syndrome by comparing lean pigs
fed a normal maintenance diet (7% kcal from fat; lean, n =
9) or excess chow with 45% kcal from fat and 2% cholesterol
(obese, n = 8). After 9 wk, body composition, glucose
tolerance, plasma lipids, and intravascular ultrasonography
and histopathology of coronary arteries were assessed.
Computed tomography (CT) assessed subcutaneous and
intra-abdominal fat deposition and was compared with
traditional methods, including anatomical measurements,
backfat ultrasonography, and proximate chemical composition
analysis. Compared with lean animals, obese swine showed
2-fold greater product of the plasma insulin × glucose
concentrations, 4.1-fold greater total cholesterol, 1.6-fold
greater postprandial triglycerides, 4.6-fold greater low- to
high-density lipoprotein cholesterol ratio, hypertension,
and neointimal hyperplasia of coronary arteries. The
1.5-fold greater body weight in obese swine was largely
accounted for by the 3-fold greater carcass fat mass. High
correlation (0.79 to 0.95) of CT, anatomical measurements,
and ultrasonography with direct chemical measures of
subcutaneous, retroperitoneal, and visceral fat indicates
high validity of all indirect methods.
TypeCount
Investigators 1


Investigators
NameInstitution
Charles PowellIndiana University-Purdue University-Indianapolis