FVB/N

Summary Data Summary
Species M. musculus
Official Name FVB/N
Common Name FVB/N
Description FVB/N was inbred for the Fv1b allele which confers
sensitivity to the Friend leukemia virus B strain. Due to
the prominent pronuclei in their fertilized eggs and the
large litter size, FVB/N mice are commonly used for
transgenic injection. Compared to many other inbred strains,
FVB/N is highly susceptible to asthma-like airway
responsiveness with significant generation of
antigen-specific IgE. Despite having the H2q MHC haplotype,
FVB/N are resistant to collagen-induced arthritis. This
resistance stems from coding polymorphisms in Tcra-V11.1 and
a genomic deletion of some Tcrb-V genes that includes
Tcrb-V8.2. FVB/N have higher than average activity, anxiety,
and basal body temperature, low stress-induced hyperthermia,
and are homozygous for the Pde6brd1 allele, which results in
early onset retinal degeneration. Although FVB/N typically
do not develop spontaneous tumors, they are highly
susceptible to chemically induced squamous cell carcinomas
with a high rate of malignant conversion from papilloma to
carcinoma.
Development Status Phenotyping ongoing
Breeding Type intercross
TypeCount