NOD/Shi

This strain is a polygenic model for type 1 diabetes. Diabetes in NOD/ShiLtJ mice is characterized by insulitis, a leukocytic infiltration of the pancreatic islets. Marked decreases in pancreatic insulin content occur in females at about 12 weeks of age and several weeks later in males. Consequently, plasma glucose levels increase to greater than 250mg/dl.


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