B6.129-Ins2Akita Bdkrb2tm1Jfh/SmiJ

Mice homozygous for this targeted mutation of the bradykinin receptor, beta 2 (Bdkrb2) gene and heterozygous for the Akita spontaneous mutation of the insulin 2 (Ins2) gene (Ins2) are viable and fertile. They are extremely diabetic, underweight, hyperphagic, polyuric, and have severe kidney, skeletal, and testicular defects. essentially no subcutaneous fat, and a significantly reduced lifespan. This strain may be used to research the kallikrein-kinin system, specifically the role of bradykinin B2 receptor in diabetes, oxidative stress, mitochondrial DNA damage, apoptosis, kidney morphology and function, and other senescence-associated phenotypes.


Phenotyped ForOther Resources
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Neuropathy Validation
IENF (num/mm)LC (num/mm)MAD (μm)MFPHPAT (sec)sciatic motor CV (m/s)SNP (num/mm)sural NCV (m/s)TFAT (sec)LengthED (mm)
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