FVB.Cg-Nr1h4tm1Gonz/J

Mice that are homozygous for the targeted Nr1h4 allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. No Nr1h4 protein product is detected in liver tissue although an aberrant transcript appears to be generated. Homozygous mice display a proatherogenic serum lipoprotein profile characterized by elevated levels of serum and hepatic cholesterol and triglycerides. Serum bile acids are also elevated. When fed a diet supplemented with 1% cholic acid, severe wasting, hypothermia and increased mortality is observed. Wildtype mice fed a similar diet display no ill effects. Levels of fecal bile excretion are reduced in homozygotes.


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Data (.csv filetype)

plasma glucose (mg/dL)

SeriesSexNAvgSD
FVB.Cg-Nr1h4tm1Gonz/JBoth84184.2560.21
 Female48186.2172.01
 Male36181.6439.13
Avg = 158.43
Std = 34.37
N = 14
Age = 24 Avg = 159.79
Std = 22.74
N = 14
Age = 20 Avg = 150.71
Std = 33.93
N = 14
Age = 16 Avg = 204.64
Std = 89.82
N = 14
Age = 12 Avg = 205.5
Std = 72.28
N = 14
Age = 8 Avg = 247.75
Std = 26.56
N = 4
Age = 5 Avg = 217.9
Std = 16.29
N = 10
Age = 4 Avg = 158.43
Std = 34.37
N = 14
Age = 24 Avg = 159.79
Std = 22.74
N = 14
Age = 20 Avg = 150.71
Std = 33.93
N = 14
Age = 16 Avg = 204.64
Std = 89.82
N = 14
Age = 12 Avg = 205.5
Std = 72.28
N = 14
Age = 8 Avg = 247.75
Std = 26.56
N = 4
Age = 5 Avg = 217.9
Std = 16.29
N = 10
Age = 4

insulin, plasma (pg/ml)

SeriesSexNAvgSD
FVB.Cg-Nr1h4tm1Gonz/JBoth421711.48869.81
 Female241374.79620.20
 Male182160.39948.59
Avg = 1807.21
Std = 959.35
N = 14
Age = 24 Avg = 1806.29
Std = 791.3
N = 14
Age = 16 Avg = 1520.93
Std = 817.77
N = 14
Age = 8 Avg = 1807.21
Std = 959.35
N = 14
Age = 24 Avg = 1806.29
Std = 791.3
N = 14
Age = 16 Avg = 1520.93
Std = 817.77
N = 14
Age = 8

W rodent (g)

SeriesSexNAvgSD
FVB.Cg-Nr1h4tm1Gonz/JBoth225.753.65
 Female122.100.00
 Male129.400.00
Avg = 25.75
Std = 3.65
N = 2

fat body mass (g)

SeriesSexNAvgSD
FVB.Cg-Nr1h4tm1Gonz/JBoth84.090.80
 Female54.100.76
 Male34.060.87
Avg = 4.09
Std = 0.8
N = 8

lean body mass (g)

SeriesSexNAvgSD
FVB.Cg-Nr1h4tm1Gonz/JBoth819.551.32
 Female518.900.98
 Male320.631.09
Avg = 19.55
Std = 1.32
N = 8

%BF (rodent) (%)

SeriesSexNAvgSD
FVB.Cg-Nr1h4tm1Gonz/JBoth817.182.16
 Female517.661.99
 Male316.392.20
Avg = 17.18
Std = 2.16
N = 8