B6.Cg-Ins2Akita Ldlrtm1Her/J

Mice homozygous for the Akita spontaneous mutation die postnatally, typically by 12 weeks of age. Independently, heterozygous Akita mutant mice are a model of insulin dependent diabetes mellitus (IDDM) with severe hyperglycemia (see the datasheet for Stock No. 003548 for additional information). LDLR-null homozygotes have elevated serum cholesterol levels (200-400 mg/dl) which can escalate to very high levels (> 2000 mg/dl) when the mice are fed a high fat diet. LDLR-deficient mice also are predisposed to develop atherosclerosis. These double mutant mice may be useful in studies of diabetes, metabolism, hyperglycemia, atherosclerosis, hypercholesterolemia, and diabetes-related macrovascular complications.


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Data (.csv filetype)

plasma glucose (mg/dL)

SeriesSexNAvgSD
B6.Cg-Ins2Akita Ldlrtm1Her/JBoth92373.10259.68
 Male92373.10259.68
Avg = 720
Std = 42
N = 2
Age = 26 Avg = 423.25
Std = 96.34
N = 4
Age = 24 Avg = 1272
Std = 0
N = 1
Age = 23 Avg = 406.53
Std = 167.4
N = 15
Age = 20 Avg = 1510
Std = 374
N = 2
Age = 17 Avg = 282.71
Std = 162.72
N = 17
Age = 16 Avg = 252.71
Std = 151.38
N = 17
Age = 12 Avg = 273.94
Std = 110.94
N = 17
Age = 8 Avg = 446.6
Std = 111.35
N = 10
Age = 6 Avg = 368.14
Std = 57.6
N = 7
Age = 4 Avg = 720
Std = 42
N = 2
Age = 26 Avg = 423.25
Std = 96.34
N = 4
Age = 24 Avg = 1272
Std = 0
N = 1
Age = 23 Avg = 406.53
Std = 167.4
N = 15
Age = 20 Avg = 1510
Std = 374
N = 2
Age = 17 Avg = 282.71
Std = 162.72
N = 17
Age = 16 Avg = 252.71
Std = 151.38
N = 17
Age = 12 Avg = 273.94
Std = 110.94
N = 17
Age = 8 Avg = 446.6
Std = 111.35
N = 10
Age = 6 Avg = 368.14
Std = 57.6
N = 7
Age = 4

insulin, plasma (pg/ml)

SeriesSexNAvgSD
B6.Cg-Ins2Akita Ldlrtm1Her/JBoth17471.41224.19
 Male17471.41224.19
Avg = 184.33
Std = 126.21
N = 3
Age = 24 Avg = 498.29
Std = 150.39
N = 7
Age = 16 Avg = 567.57
Std = 217.55
N = 7
Age = 8 Avg = 184.33
Std = 126.21
N = 3
Age = 24 Avg = 498.29
Std = 150.39
N = 7
Age = 16 Avg = 567.57
Std = 217.55
N = 7
Age = 8

W rodent (g)

SeriesSexNAvgSD
B6.Cg-Ins2Akita Ldlrtm1Her/JBoth7219.822.39
 Male7219.822.39
Avg = 18.82
Std = 1.89
N = 2
Age = 26 Avg = 19.85
Std = 1.61
N = 4
Age = 24 Avg = 19.72
Std = 1.41
N = 5
Age = 22 Avg = 21
Std = 1.26
N = 5
Age = 20 Avg = 21.52
Std = 1.12
N = 5
Age = 18 Avg = 21.8
Std = 1.57
N = 7
Age = 16 Avg = 21.64
Std = 0.75
N = 8
Age = 14 Avg = 21.63
Std = 0.58
N = 7
Age = 12 Avg = 20.03
Std = 0.69
N = 7
Age = 10 Avg = 19.27
Std = 0.63
N = 8
Age = 8 Avg = 18.14
Std = 0.4
N = 7
Age = 6 Avg = 14.36
Std = 1.02
N = 7
Age = 4 Avg = 18.82
Std = 1.89
N = 2
Age = 26 Avg = 19.85
Std = 1.61
N = 4
Age = 24 Avg = 19.72
Std = 1.41
N = 5
Age = 22 Avg = 21
Std = 1.26
N = 5
Age = 20 Avg = 21.52
Std = 1.12
N = 5
Age = 18 Avg = 21.8
Std = 1.57
N = 7
Age = 16 Avg = 21.64
Std = 0.75
N = 8
Age = 14 Avg = 21.63
Std = 0.58
N = 7
Age = 12 Avg = 20.03
Std = 0.69
N = 7
Age = 10 Avg = 19.27
Std = 0.63
N = 8
Age = 8 Avg = 18.14
Std = 0.4
N = 7
Age = 6 Avg = 14.36
Std = 1.02
N = 7
Age = 4

fat body mass (g)

SeriesSexNAvgSD
B6.Cg-Ins2Akita Ldlrtm1Her/JBoth22.920.26
 Male22.920.26
Avg = 2.92
Std = 0.26
N = 2

lean body mass (g)

SeriesSexNAvgSD
B6.Cg-Ins2Akita Ldlrtm1Her/JBoth213.801.40
 Male213.801.40
Avg = 13.8
Std = 1.4
N = 2

%BF (rodent) (%)

SeriesSexNAvgSD
B6.Cg-Ins2Akita Ldlrtm1Her/JBoth217.770.45
 Male217.770.45
Avg = 17.77
Std = 0.45
N = 2