129S6.Cg-Nos3tm1Unc Ins2Akita/J

Mice homozygous for the Nos3 targeted mutation are viable and fertile. They have elevated blood pressure that is about 20 mmHg higher than that seen in normal wildtype siblings. They also show a decreased heart rate. Female homozygotes are smaller in body weight than normal wildtype siblings. Hyperglycemic-euglycemic clamp studies demonstrate that homozygotes exhibit insulin resistance at the level of the liver and peripheral tissues. This strain includes the Akita mutation in the Insulin 2 gene.


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Data (.csv filetype)

plasma glucose (mg/dL)

SeriesSexNAvgSD
129S6.Cg-Nos3tm1Unc Ins2Akita/JBoth123610.46165.34
 Female76573.87157.28
 Male47669.62160.86
Avg = 859.85
Std = 156.85
N = 20
Age = 26 Avg = 636
Std = 86.62
N = 20
Age = 24 Avg = 637.7
Std = 70.49
N = 20
Age = 20 Avg = 589.55
Std = 84.35
N = 20
Age = 16 Avg = 521.95
Std = 104.7
N = 20
Age = 12 Avg = 450.07
Std = 88.38
N = 15
Age = 8 Avg = 429.25
Std = 84.01
N = 8
Age = 6 Avg = 859.85
Std = 156.85
N = 20
Age = 26 Avg = 636
Std = 86.62
N = 20
Age = 24 Avg = 637.7
Std = 70.49
N = 20
Age = 20 Avg = 589.55
Std = 84.35
N = 20
Age = 16 Avg = 521.95
Std = 104.7
N = 20
Age = 12 Avg = 450.07
Std = 88.38
N = 15
Age = 8 Avg = 429.25
Std = 84.01
N = 8
Age = 6

insulin, plasma (pg/ml)

SeriesSexNAvgSD
129S6.Cg-Nos3tm1Unc Ins2Akita/JBoth55455.95167.32
 Female34481.76192.98
 Male21414.14101.00
Avg = 541.05
Std = 188.8
N = 20
Age = 24 Avg = 418.1
Std = 145.76
N = 20
Age = 16 Avg = 392.93
Std = 106.09
N = 15
Age = 8 Avg = 541.05
Std = 188.8
N = 20
Age = 24 Avg = 418.1
Std = 145.76
N = 20
Age = 16 Avg = 392.93
Std = 106.09
N = 15
Age = 8

W rodent (g)

SeriesSexNAvgSD
129S6.Cg-Nos3tm1Unc Ins2Akita/JBoth19922.202.20
 Female12221.862.30
 Male7722.741.91
Avg = 22.24
Std = 1.91
N = 20
Age = 26 Avg = 24.44
Std = 1.73
N = 20
Age = 24 Avg = 23.26
Std = 1.72
N = 20
Age = 22 Avg = 23.04
Std = 1.68
N = 20
Age = 20 Avg = 23.47
Std = 1.68
N = 20
Age = 18 Avg = 22.29
Std = 1.48
N = 20
Age = 16 Avg = 22.29
Std = 1.48
N = 20
Age = 14 Avg = 21.28
Std = 1.73
N = 20
Age = 12 Avg = 20.55
Std = 1.5
N = 15
Age = 10 Avg = 19.61
Std = 1.45
N = 15
Age = 8 Avg = 18.83
Std = 1.19
N = 9
Age = 6 Avg = 22.24
Std = 1.91
N = 20
Age = 26 Avg = 24.44
Std = 1.73
N = 20
Age = 24 Avg = 23.26
Std = 1.72
N = 20
Age = 22 Avg = 23.04
Std = 1.68
N = 20
Age = 20 Avg = 23.47
Std = 1.68
N = 20
Age = 18 Avg = 22.29
Std = 1.48
N = 20
Age = 16 Avg = 22.29
Std = 1.48
N = 20
Age = 14 Avg = 21.28
Std = 1.73
N = 20
Age = 12 Avg = 20.55
Std = 1.5
N = 15
Age = 10 Avg = 19.61
Std = 1.45
N = 15
Age = 8 Avg = 18.83
Std = 1.19
N = 9
Age = 6

fat body mass (g)

SeriesSexNAvgSD
129S6.Cg-Nos3tm1Unc Ins2Akita/JBoth203.520.30
 Female123.590.22
 Male83.420.37
Avg = 3.52
Std = 0.3
N = 20

lean body mass (g)

SeriesSexNAvgSD
129S6.Cg-Nos3tm1Unc Ins2Akita/JBoth2017.541.79
 Female1217.451.80
 Male817.661.77
Avg = 17.54
Std = 1.79
N = 20

%BF (rodent) (%)

SeriesSexNAvgSD
129S6.Cg-Nos3tm1Unc Ins2Akita/JBoth2016.821.68
 Female1217.171.78
 Male816.291.38
Avg = 16.82
Std = 1.68
N = 20