129S6.Cg-Nos3tm1Unc Ins2+/+/J

Control strain for 129S6.Cg-Nos3 Ins2/J. Mice homozygous for the Nos3 targeted mutation are viable and fertile. They have elevated blood pressure that is about 20 mmHg higher than that seen in normal wildtype siblings. They also show a decreased heart rate. Female homozygotes are smaller in body weight than normal wildtype siblings. Hyperglycemic-euglycemic clamp studies demonstrate that homozygotes exhibit insulin resistance at the level of the liver and peripheral tissues.


Phenotyped ForOther Resources
Histology
Images
ReagentsPublications
No DataNo DataNo DataNo DataNo DataNo Data   


Data (.csv filetype)

plasma glucose (mg/dL)

SeriesSexNAvgSD
129S6.Cg-Nos3tm1Unc Ins2+/+/JBoth79160.5350.60
 Female36161.4756.29
 Male43159.7445.27
Avg = 232.58
Std = 79.3
N = 12
Age = 26 Avg = 158.56
Std = 15.54
N = 9
Age = 24 Avg = 160.46
Std = 13.82
N = 13
Age = 20 Avg = 163.07
Std = 14.29
N = 14
Age = 16 Avg = 133.71
Std = 25.34
N = 14
Age = 12 Avg = 128.91
Std = 42.44
N = 11
Age = 8 Avg = 134.17
Std = 21.62
N = 6
Age = 6 Avg = 232.58
Std = 79.3
N = 12
Age = 26 Avg = 158.56
Std = 15.54
N = 9
Age = 24 Avg = 160.46
Std = 13.82
N = 13
Age = 20 Avg = 163.07
Std = 14.29
N = 14
Age = 16 Avg = 133.71
Std = 25.34
N = 14
Age = 12 Avg = 128.91
Std = 42.44
N = 11
Age = 8 Avg = 134.17
Std = 21.62
N = 6
Age = 6

insulin, plasma (pg/ml)

SeriesSexNAvgSD
129S6.Cg-Nos3tm1Unc Ins2+/+/JBoth36744.50450.22
 Female16528.31205.31
 Male20917.45513.64
Avg = 734.58
Std = 169.38
N = 12
Age = 24 Avg = 875.5
Std = 640.92
N = 14
Age = 16 Avg = 573
Std = 258.14
N = 10
Age = 8 Avg = 734.58
Std = 169.38
N = 12
Age = 24 Avg = 875.5
Std = 640.92
N = 14
Age = 16 Avg = 573
Std = 258.14
N = 10
Age = 8

W rodent (g)

SeriesSexNAvgSD
129S6.Cg-Nos3tm1Unc Ins2+/+/JBoth13323.532.95
 Female5821.611.82
 Male7525.022.79
Avg = 24.37
Std = 2.47
N = 11
Age = 26 Avg = 26.18
Std = 2.68
N = 12
Age = 24 Avg = 24.32
Std = 2.49
N = 13
Age = 22 Avg = 24.73
Std = 3.04
N = 13
Age = 20 Avg = 24.75
Std = 2.69
N = 13
Age = 18 Avg = 23.48
Std = 2.75
N = 14
Age = 16 Avg = 23.48
Std = 2.75
N = 14
Age = 14 Avg = 22.56
Std = 2.35
N = 14
Age = 12 Avg = 22.15
Std = 1.86
N = 12
Age = 10 Avg = 20.76
Std = 1.89
N = 11
Age = 8 Avg = 20.12
Std = 1.44
N = 6
Age = 6 Avg = 24.37
Std = 2.47
N = 11
Age = 26 Avg = 26.18
Std = 2.68
N = 12
Age = 24 Avg = 24.32
Std = 2.49
N = 13
Age = 22 Avg = 24.73
Std = 3.04
N = 13
Age = 20 Avg = 24.75
Std = 2.69
N = 13
Age = 18 Avg = 23.48
Std = 2.75
N = 14
Age = 16 Avg = 23.48
Std = 2.75
N = 14
Age = 14 Avg = 22.56
Std = 2.35
N = 14
Age = 12 Avg = 22.15
Std = 1.86
N = 12
Age = 10 Avg = 20.76
Std = 1.89
N = 11
Age = 8 Avg = 20.12
Std = 1.44
N = 6
Age = 6

fat body mass (g)

SeriesSexNAvgSD
129S6.Cg-Nos3tm1Unc Ins2+/+/JBoth125.551.13
 Female54.370.52
 Male76.390.53
Avg = 5.55
Std = 1.13
N = 12

lean body mass (g)

SeriesSexNAvgSD
129S6.Cg-Nos3tm1Unc Ins2+/+/JBoth1217.851.81
 Female516.521.85
 Male718.801.01
Avg = 17.85
Std = 1.81
N = 12

%BF (rodent) (%)

SeriesSexNAvgSD
129S6.Cg-Nos3tm1Unc Ins2+/+/JBoth1223.502.88
 Female520.841.38
 Male725.402.06
Avg = 23.5
Std = 2.88
N = 12