C57BL/6-Ins2AkitaNos3tm1Unc/J

Mice homozygous for the Nos3 targeted mutation are viable and fertile. They have elevated blood pressure that is about 20 mmHg higher than that seen in normal wildtype siblings. They also show a decreased heart rate. Female homozygotes are smaller in body weight than normal wildtype siblings. Hyperglycemic-euglycemic clamp studies demonstrate that homozygotes exhibit insulin resistance at the level of the liver and peripheral tissues. This strain includes the Akita mutation in the Insulin 2 gene.


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Data (.csv filetype)

plasma glucose (mg/dL)

SeriesSexNAvgSD
C57BL/6-Ins2AkitaNos3tm1Unc/JBoth106391.85165.09
 Female46250.2091.94
 Male60500.45120.39
Avg = 502.75
Std = 199.94
N = 16
Age = 26 Avg = 395.12
Std = 182.18
N = 16
Age = 24 Avg = 334.75
Std = 141.93
N = 16
Age = 20 Avg = 362.81
Std = 136.41
N = 16
Age = 16 Avg = 356.56
Std = 135.09
N = 16
Age = 12 Avg = 383
Std = 147.81
N = 16
Age = 8 Avg = 417.6
Std = 128.98
N = 10
Age = 6 Avg = 502.75
Std = 199.94
N = 16
Age = 26 Avg = 395.12
Std = 182.18
N = 16
Age = 24 Avg = 334.75
Std = 141.93
N = 16
Age = 20 Avg = 362.81
Std = 136.41
N = 16
Age = 16 Avg = 356.56
Std = 135.09
N = 16
Age = 12 Avg = 383
Std = 147.81
N = 16
Age = 8 Avg = 417.6
Std = 128.98
N = 10
Age = 6

insulin, plasma (pg/ml)

SeriesSexNAvgSD
C57BL/6-Ins2AkitaNos3tm1Unc/JBoth48675.48461.44
 Female211009.19515.60
 Male27415.93133.36
Avg = 653
Std = 515.73
N = 16
Age = 24 Avg = 706.38
Std = 536.85
N = 16
Age = 16 Avg = 667.06
Std = 288.2
N = 16
Age = 8 Avg = 653
Std = 515.73
N = 16
Age = 24 Avg = 706.38
Std = 536.85
N = 16
Age = 16 Avg = 667.06
Std = 288.2
N = 16
Age = 8

W rodent (g)

SeriesSexNAvgSD
C57BL/6-Ins2AkitaNos3tm1Unc/JBoth18620.461.79
 Female8120.372.25
 Male10520.541.33
Avg = 20.61
Std = 1.91
N = 16
Age = 26 Avg = 21.33
Std = 1.91
N = 16
Age = 25 Avg = 21.97
Std = 1.78
N = 16
Age = 24 Avg = 20.93
Std = 1.84
N = 16
Age = 22 Avg = 20.61
Std = 1.48
N = 16
Age = 20 Avg = 20.71
Std = 1.68
N = 16
Age = 18 Avg = 20.61
Std = 1.38
N = 16
Age = 16 Avg = 20.29
Std = 1.33
N = 16
Age = 14 Avg = 20.18
Std = 1.26
N = 16
Age = 12 Avg = 19.83
Std = 1.25
N = 16
Age = 10 Avg = 19.29
Std = 1.44
N = 16
Age = 8 Avg = 18.43
Std = 1.61
N = 10
Age = 6 Avg = 20.61
Std = 1.91
N = 16
Age = 26 Avg = 21.33
Std = 1.91
N = 16
Age = 25 Avg = 21.97
Std = 1.78
N = 16
Age = 24 Avg = 20.93
Std = 1.84
N = 16
Age = 22 Avg = 20.61
Std = 1.48
N = 16
Age = 20 Avg = 20.71
Std = 1.68
N = 16
Age = 18 Avg = 20.61
Std = 1.38
N = 16
Age = 16 Avg = 20.29
Std = 1.33
N = 16
Age = 14 Avg = 20.18
Std = 1.26
N = 16
Age = 12 Avg = 19.83
Std = 1.25
N = 16
Age = 10 Avg = 19.29
Std = 1.44
N = 16
Age = 8 Avg = 18.43
Std = 1.61
N = 10
Age = 6

fat body mass (g)

SeriesSexNAvgSD
C57BL/6-Ins2AkitaNos3tm1Unc/JBoth163.350.41
 Female73.570.49
 Male93.170.21
Avg = 3.35
Std = 0.41
N = 16

lean body mass (g)

SeriesSexNAvgSD
C57BL/6-Ins2AkitaNos3tm1Unc/JBoth1616.141.68
 Female716.641.71
 Male915.741.54
Avg = 16.14
Std = 1.68
N = 16

%BF (rodent) (%)

SeriesSexNAvgSD
C57BL/6-Ins2AkitaNos3tm1Unc/JBoth1617.201.35
 Female717.671.41
 Male916.831.17
Avg = 17.2
Std = 1.35
N = 16