129S6-Ins2Akita/+ Gt(ROSA)26Sortm1(Jak2)Bro Tg(Nphs2-Cre)

A flox-stop-flox-Jak2 gene cassette was knocked into the Gt(ROSA)26 locus. Mice also have the Akita mutation in Ins2 with a transgene containing the Cre recombinase driven by the nephrosis 2 homolog, podocin (human) promoter. All animals are heterozygous wild type at the Ins2 locus.


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