Understanding how exposure to maternal diabetes impacts kidney development.
Jacqueline Ho   (Pittsburgh, PA)
The number of pregnant women with diabetes has increased markedly worldwide, with one estimate suggesting that as many as 1 in 14 women may be affected by diabetes during pregnancy (including women with Type 1 diabetes, Type 2 diabetes and gestational diabetes (diabetes associated with pregnancy)). Children of women with diabetes during pregnancy are more likely to have congenital anomalies of the kidneys, which are amongst the most common causes of kidney disease in children. Indeed, it has been shown that there is an increased incidence of chronic kidney disease in individuals who are exposed to maternal diabetes in utero. Our laboratory is interested in studying why children who are born to mothers with diabetes are more likely to have kidney disease. To do this, we have developed a mouse model of maternal diabetes. Mice exposed to maternal diabetes have about 20% less nephrons than mice that are born from mothers without diabetes. In this proposal, we will use this mouse model to study: (1) why the kidneys of animals exposed to diabetes before birth have fewer nephrons; and (2) whether these mice are more prone to kidney problems with age.
No report available yet.