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Pilot & Feasibility Program Application Abstract
Defining the Influence of the Gut Microbiome on Diabetic Renal Disease
Jennifer Pluznick
(Baltimore, MD)
Pilot & Feasibility Program
The intestinal lumen houses a diverse array of commensal bacteria referred to as the gut microbiota, which play a significant role in host health. Although much past work has focused on how the gut microbiota are remodeled or altered in disease, in this proposal we will focus on how the host is altered by the presence of gut microbiota. To accomplish this, we will utilize a murine model of type II diabetic kidney disease and will assay both how the gut microbiota alters diabetic renal disease in males and females, and, how the gut microbiota alters host gene expression in diabetic renal disease.
Data for this report has not yet been released.
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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