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Pilot & Feasibility Data Search


ABOUT THE DIABETIC COMPLICATIONS CONSORTIUM (FORMERLY THE AMDCC):

There is strong evidence that diabetic complications are linked via dysregulation of common pathways. The Diabetic Complications Consortium (DCC) promotes communication and collaboration between research communities investigating similar pathologic mechanisms in different organs by organizing an annual scientific meeting and funding new basic and translational research activities.

DCC Pilot & Feasibility Opportunities in 2012

The DCC is currently soliciting P&F proposals that advance the mission of the consortium.

Current areas of interest include, but are not limited to:

  • Interrogation of human samples or resources with genetics, systems biology, histology, etc.
  • Use of human tissue to better define the histo-pathology and -morphometry of organs affected by systemic diabetes. Use human tissue to identify different molecular and anatomic “subtypes” of end-organ disease.
  • Application of stem cells, including induced pluripotent stem (iPS) cells, and regenerative therapies to the repair and reversal of diabetic complications.
  • Assessment of multiple complications in model systems (C.elegans, zebrafish, drosophila, etc).
  • Testing the role of genes or loci that arise from ongoing human genetics/sequencing efforts.
  • Use of relevant model systems to accelerate gene X environment (GEI) studies.
  • Linking and coordination of existing databases relevant to complications research.
  • Pilot studies demonstrating the feasibility of pre-consenting existing cohorts for tissue collection or linking Electronic Medical Records (EMRs) to patient samples.

Budget requests should be commensurate with project needs over a one year project period. While average DCC P&F awards are $60,000 Total Costs for one year, well justified requests for support of up to $100,000 Total Costs per year will be considered.

International institutions and organizations are eligible for support.

Applications are due Thursday, May 17, 2012 for July start dates.


For instructions on how to submit a Pilot & Feasibility Funding Program Application to the DCC web portal please click the following link: Funding Program Application Submission Basic Training (PDF)
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Applicants may request up to $60,000 (direct + indirect costs) Total Costs for one year, well justified requests for support of up to $100,000. A narrative justification should be provided only for any major equipment (cost greater than $5,000) deemed to be necessary for the proposed project. The number of awards will depend upon the number, quality, duration, and cost of the applications received.

Awards will be made as subcontracts from the DCC Coordinating and Bioinformatics Unit (CBU) at the Georgia Health Sciences University and not directly by the NIH.
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Each submitted proposal will be assigned to multiple reviewers who are either members of the DCC External Evaluation Committee or external scientists with expertise in the area of a proposal. Scientists from institutions submitting a proposal are in conflict and excluded from review. Final funding decisions will be made by the NIH.
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MARCH 15, 2012 RFA for DCC Pilot Projects posted on NIH website, DCC website, MMPC websites, and notification of the postings is sent to all US academic and research institutions.
MAY 17, 2012 Grants Submitted to CBU (Dr. Richard McIndoe, CA 4127, Georgia Health Sciences University, Augusta, Georgia, 30912)
JULY 16, 2012 Projected start date for DCC Pilot Project Funding
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The application is the standard PHS 398 form including face, abstract, detailed budget, biographical and other support pages (up to 4 pages), and research plan. The research plan should include the following sections:

  1. Specific Aims,
  2. Background and Significance,
  3. Preliminary Studies,
  4. Research Design and Methods,
  5. Literature Cited,
  6. Vertebrate Animals
  7. Sharing Plan

(Sections A-D are limited to 5 PAGES). The eligibility requirements for the Pilot and Feasibility awards are limited to full time faculty that meet the criteria described below.

NOTE: Applicants should submit one (1) paper copy to the DCC CBU at the address listed below, plus submit an electronic version of the application via the DCC website (PDF format only please).

Eligible Organizations: Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Non-domestic (non-U.S.) Entity; Small Business; For-Profit Organization (Other than Small Business); State Government; Regional Organization; U.S. Territory or Possession; Indian/Native American Tribal Government (Federally Recognized); Indian/Native American Tribal Government (Other than Federally Recognized); Indian/Native American Tribally Designated Organization; Eligible agencies of the Federal government; Faith-based or community based organizations.

Eligible Project Directors/Principal Investigators: Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. Young investigators are encouraged to apply.
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Please note that projects devoted to the development of new techniques and tests for the metabolic characterization of mice are NOT responsive to this announcement and are better suited for the MMPC Pilot and Feasibility Grant Program (please see www.mmpc.org for more details). In brief, this program supports applications to:

  • Develop new technologies or miniaturization of existing technologies for use in mice,
  • Develop applications of existing technologies for use in mice,
  • Provide new tests to meet identifiable, outstanding needs necessary to phenotype mouse models of metabolic disease, and
  • Establish new types of mathematical models, informatics, databases or products that augment the mission of the center.

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A summary of progress of funded projects is due two months following the completion of the funding period.

As a DCC Pilot & Feasibility Funding Program Applicant, candidates must understand that if awarded he/she must follow the NIH and HHS policies regarding the sharing of data and resources with the scientific community (http://grants.nih.gov/grants/sharing.htm). Data and resources may include, but are not limited to:

  • histology images,
  • protocols,
  • experimental data,
  • microarray data, and
  • progress report(s).

All data and resources generated with DCC support will be made publicly available after the first of: (1) publication, or (2) two years. Two years starts at generation (i.e. uploaded to www.diacomp.org). Because it is sometimes not possible to publish or even interpret data within a two year timeframe, investigators may make a request to NIH Program staff that certain data be withheld from the public for a specified period of time.
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Richard McIndoe, Ph.D. (Coordinator)
Coordinating and Bioinformatics Unit
Georgia Health Sciences University
Center for Biotechnology and Genomic Medicine
1120 15th Street, CA4124
Augusta, GA 30912-4810
Phone: 706-721-3542
Fax: 706-721-3688
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