Murine-HumanTranscriptomic Comparisons in Diabetic Nephropathy and Neuropathy
Matthias Kretzler   (Ann Arbor, MI)
Comparison of genome-wide transcriptional profiles obtained from human and murine diabetic nephropathy (DN) and polyneuropathy (DPN) should allow identification of diabetic endorgan damage mechanisms that are conserved between mice and humans as well as those that are important in humans but whose absence in mice impairs development of full-blown DN or DPN. Targeting these pathways should greatly facilitate translation of findings from animal models to human disease and the development of improved murine models of DN and DPN.