How well do plasma cholesterol and triglyceride levels correlate with measurement of organ dysfunction across various AMDCC mouse strains?
Moshe Levi   (Washington, DC)
The role of lipids in the pathogenesis, progression, and complications of atherosclerosis and neuropathy is well established. However, the potential role of lipids in the pathogenesis and progression of nephropathy is less well established and/or appreciated. We will test the hypothesis that there are significant correlations between plasma cholesterol and/or triglyceride level and diabetic nephropathy. As a positive control we will also determine the correlation between plasma lipids and extent of atherosclerosis. Our specific aims are: 1) To examine the association of plasma total cholesterol level with the development of nephropathy in diabetic mice; 2) To examine the association of plasma triglyceride level with the development of nephropathy in diabetic mice; 3) To examine the association of plasma total cholesterol and triglyceride levels with the development of atherosclerosis in diabetic mice.