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Animal Data

Investigator	Ed Leiter
Animal ID	6867F17
Species	M. musculus
Strain	FVB.B6-Ins2Akita/MlnJ
Sex	Female
DOB
DOD

Experiments
Name Investigator Baseline Metabolic Phenotyping for DCC Mouse Strains Leiter Cardiovascular and Cardiomyopathy Phenotyping for DCC Mouse Strains Leiter Nephropathy Phenotyping for DCC Mouse Strains Leiter Neuropathy Phenotyping for DCC Mouse Strains Leiter

Phenotype Assays

Name Abbreviation Units GFR inulin clearance (FITC-inulin IV bolus injection) GFR FITC µl/min urine albumin (Exocell Albulwell M ELISA) ualb µg/ml creatinine, urine (Exocell Picric Acid method) ucreat mg/dL cholesterol, total TC mg/dL cholesterol, HDL (UC) HDL-UC mg/dL blood pressure: systole sBP mmHg body mass W rodent g urea nitrogen, blood BUN mg/dL hematocrit Hct urine albumin/urine creatinine ratio ACR µg/mg average aortic lesion area AALA µm² fatty streaks/total lesion ratio FS/total lesion complex lesions/total lesion ratio C/total lesion glomerular basement membrane thickness GBM Width μm fractional mesangial matrix volume/glomerulus Vv(MM/glom) glomerular volume Glom Vol µm³ total mesangial matrix volume Tot Mes Matrix Vol µm³ left kidney weight (mouse) L Kid Wt g right kidney weight (mouse) R Kid Wt g total albumin excretion total ualb µg average aortic leaflet A lesion AorticLesA mm² average aortic leaflet B lesion AorticLesB mm² average aortic leaflet C lesion AorticLesC mm² insulin, plasma pg/ml spleen weight Spleen Wt g spleen:body weight ratio Spleen:BW aortic sinus (cross section) lesion area μm heart rate HR bpm blood pressure: diastole dBP mmHg en face aortic arch total area EFAATA mm² en face aortic arch lesion area EFAALA mm² en face aortic arch lesion area % EFAALA% % en face thoracic aorta total area EFTATA mm² en face thoracic aorta lesion area EFTALA mm² en face thoracic aorta lesion area % EFTALA% % en face abdominal aorta total area EFAbATA mm² en face abdominal aorta lesion area EFAbALA mm² en face abdominal aorta lesion area % EFAbALA% % creatinine, serum SCR mg/dL percent body fat (rodent) %BF (rodent) % body length A/N (rodent) A/N (rodent) cm urine output urine output ml triglycerides TG mg/dL fat body mass g lean body mass g pulse bpm non-esterified free fatty acids NEFA µmol/l glucose, plasma plasma glucose mg/dL leptin ng/dl mesangial index PAS %PAS/glom bone mineral density BMD g/cm² bone mineral content BMC g bone area bone area cm² brain weight (rodent) brain weight (rodent g glutamine dehydrogenase GLDH U/L EKG-Interval between the peak of P-wave to R-wave EKG-PR msec EKG-Interval between R-waves EKG-RR msec EKG-Interval between the peak of P-wave to Q-wave EKG-PQ msec EKG-Interval between the peak of Q-wave to end of T-wave EKG-QT msec EKG-Rate-corrected QT EKG-QTc msec EKG-Beginning to end of QRS complex EKG-QRS msec EKG-Interval between the peak of S-wave to end of T-wave EKG-ST msec aortic lesion complexity index LCI Arteriolar Hyalinosis Arteriolar Hyalinosis Mesangial Sclerosis Mesangial Sclerosis Tubulo-interstitial fibrosis Tubulo-interstitial fibrosis urine albumin (spot) ualb-spot µg/ml creatinine, urine (spot) ucreatinine-spot mg/dL urine albumin/urine creatinine ratio (spot) ACR-spot µg/mg mean axonal diameter MAD μm myelinated fiber number MF intraepidermal nerve fibers IENF num/mm sub-epidermal nerve plexi SNP num/mm Pancreatic Insulin Content PIC ng/µg total length of epidermal:dermal border LengthED mm Langerhans cells LC num/mm

Models
Model Type Strain All Complications FVB.B6-Ins2Akita/MlnJ