Sign-up for our newsletter
MAIN
Event Calendar
Awardee Reports
ABOUT DIACOMP
Citing DiaComp
Contact
Committees
Institutions
Awardee Reports
Publications
Bioinformatics
RESOURCES
Protocols & Methods
Reagents & Resources
Mouse Diet
Breeding Schemes
Validation Criteria
IMPC / KOMP Data
Publications
Bioinformatics
CONTACT
PARTICIPANT AREA
Login
▹
Home
Member Profile
Jennifer Charlton
Personal Information
Title
Associate Professor
Expertise
Nephropathy
Institution
University of Virginia Health System
Newsletter?
Not signed up.
Data Summary
Type
Count
Grants/SubContracts
1
Progress Reports
1
Publications
0
Protocols
0
Committees
2
Grants/Applications
Progress Reports
Publications
Presentations
Protocols
Committees
Imaging tools and models to study the effect of preterm birth on diabetic kidney disease
Diabetic nephropathy is the leading cause of chronic kidney disease (CKD) in adults in the United States. There is an urgent unmet need to identify upstream risk factors that influence the risk and progression of diabetic kidney disease. This proposal will evaluate preterm birth as a significant risk factor in diabetic kidney disease progression. Preterm birth is common with ~10% of live births occurring before the 37th week of gestation. Those born preterm have an increased risk to develop CKD, likely due to early cessation of nephrogenesis and low nephron mass. Furthermore, studies have shown that preterm birth is a risk factor for the development of type 2 diabetes mellitus (T2DM) and females born early may be at greater risk for T2DM than preterm males. Neither clinical, nor preclinical studies, have investigated the influence of a preterm birth in the development or progression of diabetic kidney disease, representing a significant knowledge gap. Our group has developed tools to address this question and understand the molecular mechanisms that represent targetable therapeutics in this patient population. This proposal will create and investigate a diabetic mouse model born preterm using cutting-edge imaging and gene expression techniques. In Aim 1, we will characterize the structural phenotype of the kidney of a diabetic mouse model born preterm using cationic ferritin enhanced-MRI. We will use cationic ferritin enhanced-MRI to measure the glomerular number and spatially map size in diabetic mice born preterm. In Aim 2, we will compare the alterations of the kidney gene expression profiles in the diabetic preterm mouse to the diabetic term mouse. The Aims of this study align with the Diabetic Complications Consortium areas of emphasis both by advancing imaging techniques to measure nephron number as an early marker of diabetic kidney disease and examining sex differences in our model. At the conclusion of this work, we will have a fully phenotyped diabetic preterm mouse model to test therapeutic strategies for slowing progression in diabetic kidney disease.
Progress Reports
Drag a column header and drop it here to group by that column
Application
Complete Date
Report
Options
Imaging tools and models to study the effect of preterm birth on diabetic kidney disease (Charlton, Jennifer)
4/5/2023
View Progress Report Document
Annual Reports
No uploaded documents found.
Publication
Altmetrics
Submitted By
PubMed ID
Status
Options
No records to display.
No uploaded documents found.
No protocols found.
Name
Description
Steering Committee
The DiaComp Steering Committee is the governing body of the consortium. The principle function of this committee is to guide the scientific direction of the consortium. This is accomplished by creating various subcommittees necessary to advance the scientific goals and providing guidance to the broader complications research community. Policies for the consortium are developed through consultation with the
External Evaluation Committee
Nephropathy
The DiaComp Nephropathy Committee has the principal function of furthering the mission of the consortium with regard to diabetic kidney disease.
Curation Flag Information
Display Stats
New comment to be added:
Flag Active?
OrderID
Experiment
Species
Status
Measurements
Options
No records to display.
Welcome to the DiaComp Login / Account Request Page.
Email Address:
Password:
Note: Passwords are case-sensitive.
Please save my Email Address on this machine.
Not a member?
If you are a funded DiaComp investigator, a member of an investigator's lab,
or an External Scientific Panel member to the consortium, please
request an account.
Forgot your password?
Enter your Email Address and
click here.
ERROR!
There was a problem with the page:
User Info
User Confirm
Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
Citation text and image have been copied to your clipboard. You may now paste them into your document. Thank you!