Insulin signaling in the heart.
Authors Abel ED
Submitted By Submitted Externally on 10/5/2022
Status Published
Journal American journal of physiology. Endocrinology and metabolism
Year 2021
Date Published 7/1/2021
Volume : Pages 321 : E130 - E145
PubMed Reference 34056923
Abstract Insulin receptors are highly expressed in the heart and vasculature. Insulin
signaling regulates cardiac growth, survival, substrate uptake, utilization, and
mitochondrial metabolism. Insulin signaling modulates the cardiac responses to
physiological and pathological stressors. Altered insulin signaling in the heart
may contribute to the pathophysiology of ventricular remodeling and heart
failure progression. Myocardial insulin signaling adapts rapidly to changes in
the systemic metabolic milieu. What may initially represent an adaptation to
protect the heart from carbotoxicity may contribute to amplifying the risk of
heart failure in obesity and diabetes. This review article presents the multiple
roles of insulin signaling in cardiac physiology and pathology and discusses the
potential therapeutic consequences of modulating myocardial insulin signaling.

Complications