Neointimal Formation After Endovascular Arterial Injury Is Markedly Attenuated
in db/db Mice
Authors Kent Stephenson, James Tunstead, Aileen Tsai, Ron Gordon, Scott Henderson, Hayes
Submitted By Hayes Dansky on 12/16/2003
Status Published
Journal Arteriosclerosis, thrombosis, and vascular biology
Year 2003
Date Published 11/1/2003
Volume : Pages 23 : 2027 - 2033
PubMed Reference 14500292
Abstract Objective—A diabetic mouse model of accelerated neointimal formation would be a
useful tool to understand the increased
incidence of restenosis in patients with diabetes.
Methods and Results—Femoral artery endoluminal wire injury was performed in
diabetic insulin 2 Akita (ins2Akita) and
leptin receptor db/db (leprdb/db) mutant mice. Neointima size in ins2Akita mouse
arteries was unchanged compared with
nondiabetic wild-type littermates. Although Ki67 labeling demonstrated similar
rates of replication in the neointima of
leprdb/db mouse arteries, neointimal formation in leprdb/db mice was
surprisingly reduced by 90% compared with
nondiabetic lepr/ mice. Four hours after arterial injury, medial smooth muscle
cell death was diminished in leprdb/db
arteries, suggesting that the initial response to arterial injury was altered in
leprdb/db mice.
Conclusions—These studies highlight a differential response to arterial injury
in leprdb/db mice and suggest a potential role
for leptin in the regulation of neointimal formation in response to arterial

Investigators with authorship
Hayes DanskyColumbia University