Sign-up for our newsletter
MAIN
Event Calendar
Awardee Reports
ABOUT DIACOMP
Citing DiaComp
Contact
Committees
Institutions
Awardee Reports
Publications
Bioinformatics
RESOURCES
Protocols & Methods
Reagents & Resources
Mouse Diet
Breeding Schemes
Validation Criteria
IMPC / KOMP Data
Publications
Bioinformatics
CONTACT
PARTICIPANT AREA
Login
▹
Publications
▹
Home
Publication
Mouse Models of Diabetic Nephropathy
Authors
MATTHEW D. BREYER, ERWIN BÖTTINGER, FRANK C. BROSIUS, III, THOMAS M. COFFMAN,
RAYMOND C. HARRIS, CHARLES W. HEILIG, AND KUMAR SHARMA (FOR THE AMDCC)
Submitted By
Matthew Breyer on 8/4/2004
Status
Published
Journal
Journal of the American Society of Nephrology : JASN
Year
2005
Date Published
1/1/2005
Volume : Pages
16 : 27 - 45
PubMed Reference
15563560
Abstract
: Mice provide an experimental model of unparalleled flexibility for studying
mammalian diseases, including diabetic nephropathy. Inbred strains of mice
exhibit substantial differences in the renal effects of diabetes mellitus. Much
remains to be established regarding the course of diabetic nephropathy in this
species and defining those strains and/or mutants most susceptible to renal
injury from diabetes mellitus. It will be especially important to determine
whether renal function declines in any of these mouse models of diabetic
nephropathy. Technical refinements in the measurement of plasma creatinine,
glomerular filtration rate, and uniform reporting of albuminuria and
histopathology, should facilitate progress in this field and allow better
comparisons of results obtained by different laboratories. Together with the
unique genetic reagents available in mice, the identification of a mouse model
of diabetic nephropathy that closely mirrors human disease will significantly
enhance our understanding of and accelerate our progress towards a treatment for
this disease.
Investigators with authorship
Name
Institution
Erwin Bottinger
Mount Sinai School of Medicine
Matthew Breyer
Johnson & Johnson
Frank Brosius
University of Arizona
Thomas Coffman
Duke University Medical Center
Raymond Harris
Vanderbilt University
Kumar Sharma
University of California San Diego
Complications
All Complications
Bioinformatics
Bone
Cardiomyopathy
Cardiovascular
Gastro-Intestinal (GI)
Nephropathy
Neuropathy & Neurocognition
Pediatric Endocrinology
Retinopathy
Uropathy
Wound Healing
Welcome to the DiaComp Login / Account Request Page.
Email Address:
Password:
Note: Passwords are case-sensitive.
Please save my Email Address on this machine.
Not a member?
If you are a funded DiaComp investigator, a member of an investigator's lab,
or an External Scientific Panel member to the consortium, please
request an account.
Forgot your password?
Enter your Email Address and
click here.
ERROR!
There was a problem with the page:
User Info
User Confirm
Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
Citation text and image have been copied to your clipboard. You may now paste them into your document. Thank you!