Transforming growth factor-ß, bioenergetics, and mitochondria in renal disease.
Authors Casalena G, Daehn I, Bottinger E
Submitted By Erwin Bottinger on 10/31/2012
Status Published
Journal Seminars in nephrology
Year 2012
Date Published 5/1/2012
Volume : Pages 32 : 295 - 303
PubMed Reference 22835461
Abstract The transforming growth factor-ß (TGF-ß) family comprises more than 30 family
members that are structurally related secreted dimeric cytokines, including
TGF-ß, activins, and bone morphogenetic proteins/growth and differentiation
factors. TGF-ß are pluripotent regulators of cell proliferation,
differentiation, apoptosis, migration, and adhesion of many different cell
types. TGF-ß pathways are highly evolutionarily conserved and control
embryogenesis, tissue repair, and tissue homeostasis in invertebrates and
vertebrates. Aberrations in TGF-ß activity and signaling underlie a broad
spectrum of developmental disorders and major pathologies in human beings,
including cancer, fibrosis, and autoimmune diseases. Recent observations have
indicated an emerging role for TGF-ß in the regulation of mitochondrial
bioenergetics and oxidative stress responses characteristic of chronic
degenerative diseases and aging. Conversely, energy and metabolic sensory
pathways cross-regulate mediators of TGF-ß signaling. Here, we review TGF-ß and
regulation of bioenergetic and mitochondrial functions, including energy and
oxidant metabolism and apoptotic cell death, as well as their emerging relevance
in renal biology and disease.

Investigators with authorship
Erwin BottingerMount Sinai School of Medicine