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Publication

Bioenergetics in diabetic neuropathy: what we need to know.

Authors Hinder LM, Vincent AM, Burant CF, Pennathur S, Feldman EL Submitted By Eva Feldman on 10/31/2012 Status Published Journal Journal of the peripheral nervous system : JPNS Year 2012 Date Published 5/1/2012 Volume : Pages 17 Suppl 2 : 10 - 14 PubMed Reference 22548617 Abstract Progress in developing treatments for diabetic neuropathy is slowed by our limited understanding of how disturbances in metabolic substrates - glucose and fatty acids - produce nerve injury. In this review, we present the current oxidative stress hypothesis and experimental data that support it. We identify weaknesses in our understanding of diabetes-disordered metabolism in the neurovascular unit, that is, in critical cell types of the microvascular endothelium, peripheral sensory neurons, and supporting Schwann cells. Greater understanding of peripheral nervous system bioenergetics may provide insight into new drug therapies or improvements in dietary interventions in diabetes or even pre-diabetes.

Investigators with authorship
Name Institution Eva Feldman University of Michigan

Complications
All ComplicationsBioinformatics BoneCardiomyopathy CardiovascularGastro-Intestinal (GI) NephropathyNeuropathy & Neurocognition Pediatric Endocrinology Retinopathy UropathyWound Healing