Bioenergetics in diabetic neuropathy: what we need to know.
Authors Hinder LM, Vincent AM, Burant CF, Pennathur S, Feldman EL
Submitted By Eva Feldman on 10/31/2012
Status Published
Journal Journal of the peripheral nervous system : JPNS
Year 2012
Date Published 5/1/2012
Volume : Pages 17 Suppl 2 : 10 - 14
PubMed Reference 22548617
Abstract Progress in developing treatments for diabetic neuropathy is slowed by our
limited understanding of how disturbances in metabolic substrates - glucose and
fatty acids - produce nerve injury. In this review, we present the current
oxidative stress hypothesis and experimental data that support it. We identify
weaknesses in our understanding of diabetes-disordered metabolism in the
neurovascular unit, that is, in critical cell types of the microvascular
endothelium, peripheral sensory neurons, and supporting Schwann cells. Greater
understanding of peripheral nervous system bioenergetics may provide insight
into new drug therapies or improvements in dietary interventions in diabetes or
even pre-diabetes.

Investigators with authorship
Eva FeldmanUniversity of Michigan