HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients,
but not nondiabetic donors, transfer insulitis to NOD-scid/?c(null)/HLA-A2
transgenic mice concurrent with the expansion of islet-specific CD8+ T cells.
Authors Whitfield-Larry F, Young EF, Talmage G, Fudge E, Azam A, Patel S, Largay J, Byrd
W, Buse J, Calikoglu AS, Shultz LD, Frelinger JA
Submitted By Leonard Shultz on 10/31/2012
Status Published
Journal Diabetes
Year 2011
Date Published 6/1/2011
Volume : Pages 60 : 1726 - 1733
PubMed Reference 21521873
Abstract Type 1 diabetes is an autoimmune disease characterized by the destruction of
insulin-producing ß-cells. NOD mice provide a useful tool for understanding
disease pathogenesis and progression. Although much has been learned from
studies with NOD mice, increased understanding of human type 1 diabetes can be
gained by evaluating the pathogenic potential of human diabetogenic effector
cells in vivo. Therefore, our objective in this study was to develop a
small-animal model using human effector cells to study type 1 diabetes.


Investigators with authorship
NameInstitution
Leonard ShultzJackson Laboratory

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