Diabetes slows the recovery from urinary incontinence due to simulated
childbirth in female rats
Authors Ja-Hong Kim, Xiao Huang, Guiming Liu, Courtenay Moore, James Bena, Margot S.
Damaser and Firouz Daneshgari
Submitted By Firouz Daneshgari on 2/4/2009
Status Published
Journal American journal of physiology. Regulatory, integrative and comparative physiology
Year 2007
Date Published 8/1/2007
Volume : Pages 293 : R950 - R955
PubMed Reference 17491107
Abstract Diabetes slows the recovery from urinary incontinence due to simulated
childbirth in female rats. Am J Physiol Regul Integr Comp Physiol 293:
R950–R955, 2007. First published May 9, 2007;
doi:10.1152/ajpregu.00686.2006.—This study was done to test the hypothesis that
simulated vaginal birth by vaginal distension (VD)
causes more severe urinary incontinence and slower recovery in diabetic rats.
After measuring baseline leak point pressure (LPP) in 16 diabetes mellitus (DM)
and 16 age- and weight-matched control (Ct) female Sprague-Dawley rats, these
animals underwent either VD or sham VD (sham). Four and ten days after the
procedures, LPP and conscious cystometry were assessed. Tissues were then
harvested and examined by light microscopy. LPP at baseline was equal among all
four groups. Four days after VD, LPP in both VD groups dropped to significantly
lower levels than in sham rats (P  0.001). Moreover, LPP in the DMVD group was
significantly lower than in the CtVD group. At 10 days, LPP in the CtVD group
had recovered to its baseline value, whereas the LPP in the DMVD group remained
significantly reduced. DM rats had larger bladder capacity and longer
voiding intervals than Ct rats. Histological findings included more severe
damage to the external sphincter striated musculature of the urethra in DMVD
group compared with CtVD. In conclusion, these findings suggest that DM causes
increased severity and delayed functional recovery from the effects of simulated

Investigators with authorship
Firouz DaneshgariCase Western Reserve