Temporal differences in bladder dysfunction caused by diabetes, diuresis, and
treated diabetes in mice.
Authors Daneshgari F, Huang X, Liu G, Bena J, Saffore L, Powell CT
Submitted By Firouz Daneshgari on 2/4/2009
Status Published
Journal American journal of physiology. Regulatory, integrative and comparative physiology
Year 2006
Date Published 6/1/2006
Volume : Pages 290 : R1728 - R1735
PubMed Reference 16439670
Abstract Diabetic bladder dysfunction is a common complication of diabetes mellitus (DM)
with poorly understood natural history. This study examined the temporal changes
in bladder function 3, 9, 12, and 20 wk after induction of DM by streptozotocin
(STZ) in male C57BL/6 mice compared with that in age-matched diabetic mice
treated with insulin, 5% sucrose-induced diuretic mice, and sham-treated control
mice. Conscious cystometrograms of mice were examined in addition to the
measurements of micturition cycle. Diabetes resulted in decreased body weight.
Bladder weight, urine output, bladder capacity, and compliance increased in the
DM and diuretic groups. Peak voiding pressure (PVP) increased initially in both
DM and diuretic mice. However, in DM mice, PVP dropped dramatically at and after
12 wk. Similar changes in the capacity, compliance, and emptying ability of the
bladder were seen during the first 9 wk of the diabetes or diuresis, whereas
significant decline in the emptying ability of the bladder was only seen in
diabetes after 12 wk of disease in mice. Long-term insulin replacement
effectively reversed most changes in bladder function. These results suggest
that the transition from a compensated to a decompensated bladder dysfunction
occurs 9-12 wk after induction of DM in mice by STZ.

Investigators with authorship
Firouz DaneshgariCase Western Reserve