Temporal diabetes- and diuresis-induced remodeling of the urinary bladder in the
Authors Liu G, Daneshgari F.
Submitted By Firouz Daneshgari on 2/4/2009
Status Published
Journal American journal of physiology. Regulatory, integrative and comparative physiology
Year 2006
Date Published 9/1/2006
Volume : Pages 291 : R837 - R843
PubMed Reference 16513765
Abstract The natural history of diabetes mellitus-induced remodeling of the urinary
bladder is poorly understood. In this study, we examined temporal remodeling of
the bladder in diabetic and diuretic rats. Male Sprague-Dawley rats were divided
into three groups: streptozotocin-induced diabetic, 5% sucrose-induced diuretic,
and age-matched control. Micturition and morphometric characteristics were
evaluated using metabolic cages and light-microscopic examination of the bladder
4 days and 1, 2, 3, and 9 wk after induction. Digital image analysis was used to
quantify equatorial cross-sectional areas of bladder tissue and lumen, as well
as relative content of the three primary tissue components: smooth muscle,
urothelium, and collagen. Diabetes and diuresis caused significant increases in
fluid intake, urine output, and bladder weight. In both groups, progressive
increases were observed in lumen area from 4 days to 3 wk after induction and in
wall area from 2 to 3 wk after induction. Wall thickness decreased within the
first 2 wk in the diabetic and diuretic rats but returned to control at 3 and 9
wk. As a percentage of total cross-sectional area, smooth muscle area increased,
urothelium area was unchanged, and collagen area decreased in diabetic and
diuretic rats after 2-3 wk compared with control rats. In conclusion, diabetes
and diuresis induced similar bladder remodeling. Diabetes-induced diuresis
caused adaptive physical changes in rat bladder by 4 days after induction;
remodeling was observed by 2-3 wk after induction and remained stable from 3 to
9 wk.

Investigators with authorship
Firouz DaneshgariCase Western Reserve