Time dependent changes in diabetic cystopathy in rats include compensated and
decompensated bladder function.
Authors Daneshgari F, Liu G, Imrey PB
Submitted By Firouz Daneshgari on 2/4/2009
Status Published
Journal The Journal of urology
Year 2006
Date Published 7/1/2006
Volume : Pages 176 : 380 - 386
PubMed Reference 16753447
Abstract PURPOSE: Diabetic bladder dysfunction is among the most common and bothersome
complications of diabetes mellitus. While bladder filling and voiding problems
have been reported, the precise functional changes in diabetic bladders remain
unclear. We investigated time dependent changes in bladder function in
streptozotocin induced diabetic rats. MATERIALS AND METHODS: Cystometrograms and
detrusor muscle contractility were examined in male age matched control and
diabetic Sprague-Dawley rats (Harlan, Indianapolis, Indiana) 3, 6, 9, 12 and 20
weeks after diabetes induction with streptozotocin. RESULTS: Diabetes decreased
average body weight and increased bladder weight, capacity and compliance. Peak
detrusor leak pressure increased gradually from weeks 3 to 6 to 9 in diabetic
rats (mean +/- SEM 47.3 +/- 2.5, 50.8 +/- 3.0 and 56.0 +/- 3.6 cm H(2)O) and in
controls (36.9 +/- 1.4, 37.7 +/- 1.5 and 41.6 +/- 1.81 cm H(2)O, respectively).
However, at 12 and 20 weeks diabetic rats deviated strongly from this trend with
peak detrusor leak pressure decreasing vs controls (41.6 +/- 2.8 and 37.3 +/-
0.9 vs 45.2 +/- 1.7 and 49.6 +/- 1.4 cm H(2)O, respectively) and post-void
resting pressures increasing from 9-week levels vs controls (interactions p
<0.0001). In contractility studies increased contractile force responses of
diabetic animals to carbamylcholine chloride, potassium chloride, adenosine
5'-triphosphate and electric field stimulation peaked at 6 or 9 weeks but at 12
to 20 weeks they generally reverted toward those of controls (carbamylcholine
chloride and electrical field stimulation interactions p = 0.0022 and 0.01,
respectively). CONCLUSIONS: Diabetic bladders may undergo a transition from a
compensated to a decompensated state and transition in the streptozotocin rat
model may begin 9 to 12 weeks after induction.

Investigators with authorship
Firouz DaneshgariCase Western Reserve