TGF-beta in renal injury and disease.
Authors Böttinger EP
Submitted By Erwin Bottinger on 2/8/2009
Status Published
Journal Seminars in nephrology
Year 2007
Date Published 5/1/2007
Volume : Pages 27(3) : 309 - 320
PubMed Reference 17533008
Abstract Chronic progressive kidney diseases typically are characterized by loss of
differentiated epithelial cells and activation of mesenchymal cell populations
leading to renal fibrosis in response to a broad range of diverse renal
injuries. Recent evidence has indicated that epithelial microinjury leads to
unbalanced epithelial-mesenchymal communication to initiate the fibrotic
response. Transforming growth factors beta constitute a large family of
cytokines that control key cellular responses in development and tissue repair.
Activation of autocrine and paracrine transforming growth factor-beta signaling
cascades in the context of epithelial microinjuries initiate a variety of cell
type-dependent signaling and activity profiles, including epithelial apoptosis
and epithelial-to-mesenchymal transition, that trigger fibrogenic foci and
initiate progressive fibrogenesis in chronic renal injury.


Investigators with authorship
NameInstitution
Erwin BottingerMount Sinai School of Medicine

Complications









Genes
SymbolDescription
Ltbp1latent transforming growth factor beta binding protein 1
Tgfb1transforming growth factor, beta 1