Localization of the GLUT8 glucose transporter in murine kidney and regulation in
vivo in nondiabetic and diabetic conditions.
Authors Schiffer M, Susztak K, Ranalletta M, Raff AC, Böttinger EP, Charron MJ
Submitted By Erwin Bottinger on 2/8/2009
Status Published
Journal American journal of physiology. Renal physiology
Year 2005
Date Published 7/1/2005
Volume : Pages 289(1) : F186 - F193
PubMed Reference 15741607
Abstract Kidney disease is a major complication of diabetes, and poor glycemic control is
associated with the development of diabetic nephropathy. The precise mechanisms
that lead to diabetic kidney disease still remain largely unknown and are under
current investigation. Because glucose transporters in the kidney play an
important role in the local maintenance of intracellular glucose and plasma
glucose homeostasis, the tissue distribution and regulation of glucose
transporter GLUT8, a new member of the glucose transporter family with important
functions in cellular survival, were examined. To understand the normal
regulation of GLUT8 expression in response to metabolic signals, fasting and
feeding conditions were studied. Additionally, GLUT8 expression was studied
using two different models of insulin resistance, GLUT4-/- and db/db mice. GLUT8
was localized to glomerular podocytes and tubular epithelial cells in the distal
portion of the nephron. Expression of GLUT8 in the kidney was influenced by
plasma glucose levels in vivo. Podocytes in kidneys of diabetic db/db mice
express higher levels of GLUT8 compared with nondiabetic db/m mice. Because
podocytes play an important role in glomerulosclerosis development and high
levels of glucose have been shown to induce apoptotic cell death in various
kidney cells, these data may provide further insight into the pathogenesis of
glomerulosclerosis and diabetic nephropathy.


Investigators with authorship
NameInstitution
Erwin BottingerMount Sinai School of Medicine

Complications









Genes
SymbolDescription
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 4
Slc2a8solute carrier family 2, (facilitated glucose transporter), member 8