Metabolic syndrome as a modifier of atherosclerosis in murine models.
Authors Péterfy M, Davis RC, Lusis AJ
Submitted By Richard Davis on 2/8/2009
Status Published
Journal Current drug targets
Year 2007
Date Published 11/1/2007
Volume : Pages 8(11) : 1215 - 1220
PubMed Reference 18045100
Abstract The Metabolic Syndrome is a common metabolic disease associated with an
increased risk for atherosclerotic cardiovascular disease and mortality. In
contrast to "traditional" risk factors for atherosclerosis, such as low-density
lipoprotein cholesterol, the Metabolic Syndrome represents a network of
interacting risk factors stemming from the metabolic complexity of this disease.
For this reason, dissection of the cellular and molecular pathways underlying
atherosclerosis-susceptibility in the Metabolic Syndrome has been difficult. To
facilitate this endeavor, several murine models have been recently developed.
Despite their imperfect representation of the Metabolic Syndrome and
atherosclerosis in humans, these models have provided important mechanistic
insights and revealed novel molecular pathways. Furthermore, murine models are
invaluable for the evaluation of therapeutic approaches and will no doubt
facilitate the genetic dissection of atherosclerosis-susceptibility in the
Metabolic Syndrome.

Investigators with authorship
Richard DavisUniversity of California Los Angeles