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Publications
Publication
Insulin-like growth factors in the peripheral nervous system.
Authors
Sullivan KA, Kim B, Feldman EL
Submitted By
Eva Feldman on 2/8/2009
Status
Published
Journal
Endocrinology
Year
2008
Date Published
12/1/2008
Volume : Pages
149(12) : 5963 - 5971
PubMed Reference
18719018
Abstract
IGF-I and -II are potent neuronal mitogens and survival factors. The actions of
IGF-I and -II are mediated via the type I IGF receptor (IGF-IR) and IGF binding
proteins regulate the bioavailability of the IGFs. Cell viability correlates
with IGF-IR expression and intact IGF-I/IGF-IR signaling pathways, including
activation of MAPK/phosphatidylinositol-3 kinase. The expression of IGF-I and
-II, IGF-IR, and IGF binding proteins are developmentally regulated in the
central and peripheral nervous system. IGF-I therapy demonstrates mixed
therapeutic results in the treatment of peripheral nerve injury, neuropathy, and
motor neuron diseases such as amyotrophic lateral sclerosis. In this review we
discuss the role of IGFs during peripheral nervous system development and the
IGF signaling system as the potential therapeutic target for the treatment of
nerve injury and motor neuron diseases.
Investigators with authorship
Name
Institution
Eva Feldman
University of Michigan
Complications
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Genes
Symbol
Description
Igf1
insulin-like growth factor 1
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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