Bladder dysfunction in mice with experimental autoimmune encephalomyelitis.
Authors Altuntas CZ, Daneshgari F, Liu G, Fabiyi A, Kavran M, Johnson JM, Gulen MF,
Jaini R, Li X, Frenkl TL, Tuohy VK
Submitted By Firouz Daneshgari on 2/8/2009
Status Published
Journal Journal of neuroimmunology
Year 2008
Date Published 10/15/2008
Volume : Pages 203(1) : 58 - 63
PubMed Reference 18703233
Abstract The vast majority of patients with multiple sclerosis (MS) develop bladder
control problems including urgency to urinate, urinary incontinence, frequency
of urination, and retention of urine. Over 60% of MS patients show
detrusor-sphincter dyssynergia, an abnormality characterized by obstruction of
urinary outflow as a result of discoordinated contraction of the urethral
sphincter muscle and the bladder detrusor muscle. In the current study we
examined bladder function in female SWXJ mice with different defined levels of
neurological impairment following induction of experimental autoimmune
encephalomyelitis (EAE), an animal model of central nervous system inflammation
widely used in MS research. We found that EAE mice develop profound bladder
dysfunction characterized by significantly increased micturition frequencies and
significantly decreased urine output per micturition. Moreover, we found that
the severity of bladder abnormalities in EAE mice was directly related to the
severity of clinical EAE and neurologic disability. Our study is the first to
show and characterize micturition abnormalities in EAE mice thereby providing a
most useful model system for understanding and treating neurogenic bladder.

Investigators with authorship
Firouz DaneshgariCase Western Reserve