Sign-up for our newsletter
MAIN
Event Calendar
Awardee Reports
ABOUT DIACOMP
Citing DiaComp
Contact
Committees
Institutions
Awardee Reports
Publications
Bioinformatics
RESOURCES
Protocols & Methods
Reagents & Resources
Mouse Diet
Breeding Schemes
Validation Criteria
IMPC / KOMP Data
Publications
Bioinformatics
CONTACT
PARTICIPANT AREA
Login
▹
Publications
▹
Home
Publication
Examining diabetic nephropathy through the lens of mouse genetics.
Authors
Breyer MD, Tchekneva E, Qi Z, Takahashi T, Fogo AB, Harris RC
Submitted By
Raymond Harris on 2/8/2009
Status
Published
Journal
Current diabetes reports
Year
2007
Date Published
12/1/2007
Volume : Pages
7(6) : 459 - 466
PubMed Reference
18255011
Abstract
Although diabetic nephropathy occurs in only a minority of patients with
diabetes, it is the major cause of end-stage renal disease in the United States.
Hyperglycemia and hypertension are important factors predisposing patients to
diabetic nephropathy, but accumulating evidence points to critical genetic
factors predisposing only a subset of patients with diabetes to nephropathy. It
has been challenging to define the genes conferring risk for nephropathy in
human populations. Comparative genomics using the robust genetic reagents
available in laboratory mice should provide a complementary approach to defining
genes that may predispose to diabetic nephropathy in mice and humans. This
article reviews new studies to identify genetic risk factors for diabetic
nephropathy and the unique approaches that may be used to elucidate the genetic
pathogenesis of this disorder in mice.
Investigators with authorship
Name
Institution
Matthew Breyer
Johnson & Johnson
Raymond Harris
Vanderbilt University
Takamune Takahashi
Vanderbilt University
Complications
All Complications
Bioinformatics
Bone
Cardiomyopathy
Cardiovascular
Gastro-Intestinal (GI)
Nephropathy
Neuropathy & Neurocognition
Pediatric Endocrinology
Retinopathy
Uropathy
Wound Healing
Welcome to the DiaComp Login / Account Request Page.
Email Address:
Password:
Note: Passwords are case-sensitive.
Please save my Email Address on this machine.
Not a member?
If you are a funded DiaComp investigator, a member of an investigator's lab,
or an External Scientific Panel member to the consortium, please
request an account.
Forgot your password?
Enter your Email Address and
click here.
ERROR!
There was a problem with the page:
User Info
User Confirm
Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
Citation text and image have been copied to your clipboard. You may now paste them into your document. Thank you!