Insight into the genetics of diabetic nephropathy through the study of mice.
Authors Breyer MD, Qi Z, Tchekneva EE, Harris RC
Submitted By Raymond Harris on 2/8/2009
Status Published
Journal Current opinion in nephrology and hypertension
Year 2008
Date Published 1/1/2008
Volume : Pages 17(1) : 82 - 86
PubMed Reference 18090675
Abstract PURPOSE OF REVIEW: To discuss mouse models of diabetic nephropathy and their use
in discovering genetic risk factors predisposing to diabetic nephropathy. RECENT
FINDINGS: Despite occurring in only 10-40% of diabetic patients, diabetic
nephropathy is the largest single cause of end stage renal disease in the USA.
Accumulated evidence points to critical genetic factors that predispose a subset
of diabetic patients to nephropathy.Defining the genes that confer risk for
nephropathy in human populations has proven challenging. The use of robust
genetic reagents available in the laboratory mouse provides a complementary
approach to defining genes that predispose to diabetic nephropathy in mice and
humans. These findings support the existence of dominant mutations predisposing
to diabetic nephropathy in mice as well as substantiating an important role for
eNOS in forestalling the development of diabetic nephropathy. SUMMARY: When
studied for a sufficient duration of diabetic hyperglycemia, some strains of
mice exhibit changes similar to those of human diabetic nephropathy. The unique
genetic reagents in mice should help accelerate the identification of genes
predisposing to diabetic nephropathy.

Investigators with authorship
Matthew BreyerJohnson & Johnson
Raymond HarrisVanderbilt University


Nos3nitric oxide synthase 3, endothelial cell