Regulation of transforming growth factor beta in diabetic nephropathy:
implications for treatment.
Authors Zhu Y, Usui HK, Sharma K
Submitted By Kumar Sharma on 2/8/2009
Status Published
Journal Seminars in nephrology
Year 2007
Date Published 3/1/2007
Volume : Pages 27(2) : 153 - 160
PubMed Reference 17418684
Abstract The recognition that the drivers of matrix accumulation is an appropriate
therapeutic target for diabetic nephropathy is now accepted by the nephrology
and pharmaceutical communities. Interventions focused around transforming growth
factor-beta (TGF-beta) likely will be an important area of clinical
investigation in the near future. Understanding the various pathways involved in
stimulating TGF-beta in the diabetic kidney is of paramount importance in
devising strategies to combat the development and progression of diabetic
nephropathy. In this review we highlight the major pathways involved in
stimulating TGF-beta production by increased glucose levels and discuss the
therapeutic implications thereof.

Investigators with authorship
Kumar SharmaUniversity of California San Diego


Ltbp1latent transforming growth factor beta binding protein 1
Tgfb1transforming growth factor, beta 1