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Publication

Regulation of transforming growth factor beta in diabetic nephropathy: implications for treatment.

Authors Zhu Y, Usui HK, Sharma K Submitted By Kumar Sharma on 2/8/2009 Status Published Journal Seminars in nephrology Year 2007 Date Published 3/1/2007 Volume : Pages 27(2) : 153 - 160 PubMed Reference 17418684 Abstract The recognition that the drivers of matrix accumulation is an appropriate therapeutic target for diabetic nephropathy is now accepted by the nephrology and pharmaceutical communities. Interventions focused around transforming growth factor-beta (TGF-beta) likely will be an important area of clinical investigation in the near future. Understanding the various pathways involved in stimulating TGF-beta in the diabetic kidney is of paramount importance in devising strategies to combat the development and progression of diabetic nephropathy. In this review we highlight the major pathways involved in stimulating TGF-beta production by increased glucose levels and discuss the therapeutic implications thereof.

Investigators with authorship
Name Institution Kumar Sharma University of California San Diego

Complications
All ComplicationsBioinformatics BoneCardiomyopathy CardiovascularGastro-Intestinal (GI) NephropathyNeuropathy & Neurocognition Pediatric Endocrinology Retinopathy UropathyWound Healing

Genes
Symbol Description Ltbp1 latent transforming growth factor beta binding protein 1 Tgfb1 transforming growth factor, beta 1