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Publication
The kallikrein-kinin system in health and in diseases of the kidney
Authors
Kakoki M, Smithies O
Submitted By
Oliver Smithies on 2/10/2009
Status
Published
Journal
Kidney international
Year
2009
Date Published
5/1/2009
Volume : Pages
Not Specified
:
Not Specified
PubMed Reference
19190676
Abstract
Since kallikrein was discovered as a vasodilatory substance in human urine, the
kallikrein-kinin system (KKS) has been considered to play a physiological role
in controlling blood pressure. Gene targeting experiments in mice in which the
KKS has been inactivated to varying degrees have, however, questioned this role,
because basal blood pressures are not altered. Rather, these experiments have
shown that the KKS has a different and important role in preventing changes
associated with normal senescence in mice, and in reducing the nephropathy and
accelerated senescence-associated phenotypes induced in mice by diabetes. Other
experiments have shown that the KKS suppresses mitochondrial respiration, partly
by nitric oxide and prostaglandins, and that this suppression may be a key to
understanding how the KKS influences senescence-related diseases. Here we review
the logical progression and experimental data leading to these conclusions, and
discuss their relevance to human conditions.Kidney International advance online
publication, 4 February 2009; doi:10.1038/ki.2008.647.
Investigators with authorship
Name
Institution
Oliver Smithies
University of North Carolina
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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