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Publications
Publication
A genome-wide set of congenic mouse strains derived from CAST/Ei on a C57BL/6
background.
Authors
Davis RC, Jin A, Rosales M, Yu S, Xia X, Ranola K, Schadt EE, Lusis AJ
Submitted By
Richard Davis on 2/11/2009
Status
Published
Journal
Genomics
Year
2007
Date Published
9/1/2007
Volume : Pages
90(3) : 306 - 313
PubMed Reference
17600671
Abstract
We previously reported the construction of two sets of heterozygous congenic
strains spanning the mouse genome. For both sets, C57BL/6J was employed as the
background strain while DNA from either DBA/2 or CAST/Ei was introgressed to
form the congenic region. We have subsequently bred most of these strains to
produce homozygous breeding stocks. Here, we report the characterization of the
strain set based on CAST/Ei. CAST/Ei is the most genetically distant strain
within the Mus mus species and many trait variations relevant to common diseases
have been identified in CAST/Ei mice. Despite breeding difficulties for some
congenic regions, presumably due to incompatible allelic variations between
CAST/Ei and C57BL/6, the resulting congenic strains cover about 80% of the
autosomal chromosomes and will be useful as a resource for the further analysis
of quantitative trait loci between the strains.
Investigators with authorship
Name
Institution
Richard Davis
University of California Los Angeles
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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