The oxidative stress status in diabetes mellitus and diabetic nephropathy.
Authors Pan HZ, Zhang L, Guo MY, Sui H, Li H, Wu WH, Qu NQ, Liang MH, Chang D
Submitted By Submitted Externally on 12/10/2012
Status Published
Journal Acta diabetologica
Year 2010
Date Published 12/1/2010
Volume : Pages 47 : 71 - 76
PubMed Reference 19475334
Abstract The aim of this study is to assess the oxidative stress status in diabetes
mellitus (DM) and diabetic nephropathy. The study group comprised 40 control
subjects, 40 type 2 DM patients without complications and 37 diabetic
nephropathies. Compared with control subjects, superoxide dismutase, glutathione
peroxidase, catalase, vitamin C were decreased (P < 0.01). There was a
significant increase in serum malondialdehyde (MDA), conjugated diene (CD),
advanced oxidation protein products (AOPP), protein carbonyl (PC) and
8-hydroxy-2'-deoxyguanosine (8-OHdG) in diabetes patients when compared with
normal subjects (P < 0.01). Moreover, these indexes were much higher in diabetic
nephropathy than that of diabetic patients without vascular complications (P <
0.05, P < 0.01). There was a significant correlation between the serum glucose
levels and PC, 8-OHdG (P < 0.05, P < 0.01). There were highly significant
positive correlation of CD and MDA, AOPP and PC (P < 0.01). Plasma AOPP levels
had a significant correlation with PC levels (P < 0.01). Our findings suggested
that diabetes patients have more severe oxidative stress than normal persons and
higher oxidative stress in diabetic nephropathy than those in patients without
complications. Oxidative stress may play an important intermediary role in the
pathogenesis of diabetes complications.

Complications