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Publication

Overexpression of human HSP27 protects sensory neurons from diabetes.

Authors Korngut L, Ma CH, Martinez JA, Toth CC, Guo GF, Singh V, Woolf CJ, Zochodne DW Submitted By Douglas Zochodne on 12/10/2012 Status Published Journal Neurobiology of disease Year 2012 Date Published 9/1/2012 Volume : Pages 47 : 436 - 443 PubMed Reference 22569359 Abstract To evaluate whether augmenting neuronal protective mechanisms might slow or arrest experimental diabetic peripheral neuropathy (DPN). DPN is one of the most common neurodegenerative disorders and is rising in prevalence. How it targets sensory neurons is uncertain; the disorder is irreversible and untreatable. We explored the intrinsic protective properties of overexpressed human HSP27 on experimental DPN. HSP27 is a small pro-survival heat shock protein that also increases axonal regeneration.

Investigators with authorship
Name Institution Douglas Zochodne University of Alberta

Complications
All Complications Bioinformatics Bone Cardiomyopathy Cardiovascular Gastro-Intestinal (GI) Nephropathy Neuropathy & Neurocognition Pediatric Endocrinology Retinopathy Uropathy Wound Healing