GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in
diabetic mice.
Authors Jolivalt CG, Fineman M, Deacon CF, Carr RD, Calcutt NA
Submitted By Nigel Calcutt on 1/30/2013
Status Published
Journal Diabetes, obesity & metabolism
Year 2011
Date Published 11/1/2011
Volume : Pages 13 : 990 - 1000
PubMed Reference 21635674
Abstract Glucagon-like peptide-1 (GLP-1) is an incretin hormone that induces
glucose-dependent insulin secretion and may have neurotrophic properties. Our
aim was to identify the presence and activity of GLP-1 receptors (GLP-1Rs) in
peripheral nerve and to assess the impact of GLP-1R agonists on diabetes-induced
nerve disorders.

Investigators with authorship
Nigel CalcuttUniversity of California San Diego