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Publication
Mechanisms of lipotoxicity in the cardiovascular system.
Authors
Wende AR, Symons JD, Abel ED
Submitted By
E. Dale Abel on 7/10/2013
Status
Published
Journal
Current hypertension reports
Year
2012
Date Published
12/1/2012
Volume : Pages
14 : 517 - 531
PubMed Reference
23054891
Abstract
Cardiovascular diseases account for approximately one third of all deaths
globally. Obese and diabetic patients have a high likelihood of dying from
complications associated with cardiovascular dysfunction. Obesity and diabetes
increase circulating lipids that upon tissue uptake, may be stored as
triglyceride, or may be metabolized in other pathways, leading to the generation
of toxic intermediates. Excess lipid utilization or activation of signaling
pathways by lipid metabolites may disrupt cellular homeostasis and contribute to
cell death, defining the concept of lipotoxicity. Lipotoxicity occurs in
multiple organs, including cardiac and vascular tissues, and a number of
specific mechanisms have been proposed to explain lipotoxic tissue injury. In
addition, recent data suggests that increased tissue lipids may also be
protective in certain contexts. This review will highlight recent progress
toward elucidating the relationship between nutrient oversupply, lipotoxicity,
and cardiovascular dysfunction. The review will focus in two sections on the
vasculature and cardiomyocytes respectively.
Investigators with authorship
Name
Institution
E. Dale Abel
University of Iowa
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Please acknowledge all posters, manuscripts or scientific materials that were generated in part or whole using funds from the Diabetic Complications Consortium(DiaComp) using the following text:
Financial support for this work provided by the NIDDK Diabetic Complications Consortium (RRID:SCR_001415, www.diacomp.org), grants DK076169 and DK115255
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