Sign-up for our newsletter

Publication

Podocyte ACE2 protects against diabetic nephropathy.

Authors Harris RC Submitted By Raymond Harris on 7/10/2013 Status Published Journal Kidney international Year 2012 Date Published 8/1/2012 Volume : Pages 82 : 255 - 256 PubMed Reference 22791320 Abstract As new components of the renin-angiotensin system (RAS) are elucidated, our understanding of the complexities of their interactions also advances. Previous studies have determined that podocytes possess a local RAS that can generate angiotensin II. Podocytes have also been shown to express angiotensin-converting enzyme 2 (ACE2), which can decrease angiotensin II levels by generation of angiotensin-(1-7). Nadarajah et al. now show that increased podocyte ACE2 activity can attenuate the development of diabetic nephropathy.

Investigators with authorship
Name Institution Raymond Harris Vanderbilt University

Complications
All ComplicationsBioinformatics BoneCardiomyopathy CardiovascularGastro-Intestinal (GI) NephropathyNeuropathy & Neurocognition Pediatric Endocrinology Retinopathy UropathyWound Healing