Transcriptome analysis of proximal tubular cells (HK-2) exposed to urines of
type 1 diabetes patients at risk of early progressive renal function decline.
Authors Wanic K, Krolewski B, Ju W, Placha G, Niewczas MA, Walker W, Warram JH, Kretzler
M, Krolewski AS
Submitted By Submitted Externally on 7/10/2013
Status Published
Journal PLoS ONE
Year 2013
Date Published 12/1/2012
Volume : Pages 8 : e57751
PubMed Reference 23505438
Abstract In patients with Type 1 Diabetes (T1D) who develop microalbuminuria, progressive
decline in glomerular filtration rate (GFR) may be initiated by leakage into the
urine of toxic proteins (txUPs). This study tested this hypothesis.

Investigators with authorship
Matthias KretzlerUniversity of Michigan