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Publication

The Link Between Obesity and Albuminuria: Adiponectin and Podocyte Dysfunction

Authors Kumar Sharma Submitted By Kumar Sharma on 3/18/2009 Status Published Journal Kidney international Year 2009 Date Published 7/1/2009 Volume : Pages 76(2) : 145 - 148 PubMed Reference 19404275 Abstract With the recent rise in world wide obesity, obesity-related albuminuria is now being recognized as a critical risk factor for cardiovascular disease. However, there is an urgent need to better understand this association. Recent clinical studies suggest that the adipocyte hormone adiponectin may play a key role in the development of obesity-related albuminuria. Moreover, studies with the adiponectin knockout mouse indicate that adiponectin can regulate podocyte function and thus contribute to the initial development of albuminuria. Future studies to examine adipocyte-renal cell biology are needed to develop preventive and therapeutic strategies for combatting the complications of obesity.

Investigators with authorship
Name Institution Kumar Sharma University of California San Diego

Complications
All ComplicationsBioinformatics BoneCardiomyopathy CardiovascularGastro-Intestinal (GI) NephropathyNeuropathy & Neurocognition Pediatric Endocrinology Retinopathy UropathyWound Healing

Genes
Symbol Description Adipoq adiponectin, C1Q and collagen domain containing